Neurophysiological Modelling of Corticothalamic Dynamics in the Waking EEG

Proposal details

Title: Neurophysiological Modelling of Corticothalamic Dynamics in the Waking EEG
Research Area(s): ADHD and Allied Conditions
Background:
Aims: A computer model of EEG activity in the brain is outlined providing a unified and testable explanation of the major EEG rhythms in different states of arousal. The model incorporates macroscopic intracortical, cortico-cortical and corticothalamic pathways, and microscopic neural properties including synaptic activation, separate excitatory and inhibitory connections, dendritic propagation, firing thresholds and axonal conduction.
Method: To test the model and determine its neurophysiological parameters the model’s linear spectrum was fitted to the EEG data of 100 normals in relaxed eyes-closed and eyes-open states. A paired samples t-test was used to ascertain which cortical parameters varied significantly between the two states, and a correlation matrix was used to compare the model parameters to traditional measures of QEEG for slow wave, delta, theta, alpha, beta and gamma band powers.