Identifying Biological Markers for PTSD

Proposal details

Title: Identifying Biological Markers for PTSD
Research Area(s): PTSD and other Anxiety Disorders
Background: The fMRI protocol used in the schizophrenia study will also be applied to PTSD to examine differential disturbances in this disorder. PTSD also involves severe emotional disturbances. Animal research suggests specific brain networks in the limbic system – observable with fMRI – are causally involved in the development and maintenance of PTSD. Brain Dynamics Centre research shows that eye movements to threat-related stimuli are disturbed in PTSD. PTSD also involves greatly increased arousal. Our fully integrated fMRI-arousal-eye movement technique will therefore be extremely applicable in this project. No other centre in the world has the means to explore simultaneously both brain network and arousal dysfunctions in PTSD. Our collaborator on the PTSD project, Assoc. Prof. Richard Bryant, is the main advisor to the Australian Govt. on PTSD and associated medico-legal issues. Because we have the unique fMRI-arousal system Prof Bryant is keen to link to us, and to explore fully the implications of our results for clinical practice and policy.
Aims: The fMRI protocol used in the schizophrenia study will also be applied to PTSD to examine differential disturbances in this disorder. PTSD also involves severe emotional disturbances. Animal research suggests specific brain networks in the limbic system – observable with fMRI – are causally involved in the development and maintenance of PTSD. Brain Dynamics Centre research shows that eye movements to threat-related stimuli are disturbed in PTSD. PTSD also involves greatly increased arousal. Our fully integrated fMRI-arousal-eye movement technique will therefore be extremely applicable in this project. No other centre in the world has the means to explore simultaneously both brain network and arousal dysfunctions in PTSD. Our collaborator on the PTSD project, Assoc. Prof. Richard Bryant, is the main advisor to the Australian Govt. on PTSD and associated medico-legal issues. Because we have the unique fMRI-arousal system Prof Bryant is keen to link to us, and to explore fully the implications of our results for clinical practice and policy.
Method: