Disconnectivity in affective disorders

Proposal details

Title: Disconnectivity in affective disorders
Research Area(s): Brain Imaging
Background: A fundamental problem in cognitive neuroscience, and its application to central nervous system disorders, concerns how to link insights about brain function to the abnormal behaviours that they control. The focus on distributed brain systems and their coordination offers an appropriate framework for investigating this disorder.
Aims: This study aims to investigate the thalamo-cortico-amygdala network involved in the perception of emotionally salient faces and the modulation of this network by the higher order prefrontal cortex. The central hypothesis of the proposed project is that affective disorder groups, such as schizophrenia and post traumatic stress disorder, will show a breakdown in this network.
Method: Data analysis will use the interaction analyses techniques along with a novel methodology developed by our group, which enables the study of correlations between different spatial scales across chosen brain networks, to determine effective connectivity in the distributed spatial structures involved in the emotion perception process and to probe network disconnectivity in affective disorder groups