The neural correlates of response inhibition in Post-Traumatic Stress Disorder (PTSD)

Proposal details

Title: The neural correlates of response inhibition in Post-Traumatic Stress Disorder (PTSD)
Research Area(s): PTSD and other Anxiety Disorders
Background: Post-Traumatic Stress Disorder (PTSD) involves deficits in information processing, particularly deficits in working memory and in task performance involving the resolution of interfering information (i.e., the Stroop task). These performance deficits may reflect changes in inhibitory processing in PTSD. The neural correlates of inhibitory processing (particularly motor response inhibition) in PTSD has not been investigated. One study (Mackenzie et al., 2002) has found that response inhibition in a traumatized pediatric population involves decreased cortical activation accompanied by increased activity in brain areas that are associated with autonomic arousal.
Aims: Our aim is to determine the neurophysiological correlates of response inhibition in a PTSD population.
Method: Neural activation associated with response inhibition will be investigated in subjects meeting criteria for PTSD (using the Clinician Administered PTSD Scale), using fMRI and EEG recordings during performance of a Go/No Go behavioural task.