Relationship between patterns of cortical and peripheral arousal in PTSD

Proposal details

Title: Relationship between patterns of cortical and peripheral arousal in PTSD
Research Area(s): PTSD and other Anxiety Disorders
Background: PTSD is hypothesised to be a disorder of excessive central nervous system arousal. Measures of peripheral arousal, such as heart rate and blood pressure are often found to be elevated in PTSD, while cortical arousal (qEEG) has rarely been investigated. The relationship between qEEG and autonomic arousal has not been investigated in the same population.
Aims: The aim of the current research is to investigate patterns of qEEG abnormality in a PTSD population based and current models of the effects of generalised arousal and emotional states on the brain. To investigate the relationship between patterns of qEEG and autonomic arousal and clinical symtpoms. The specific hypotheses are 1. increased beta and decreased alpha power 2. decreased frontal activation 3. increased right hemisphere relative to left hemisphere actviation
Method: The project will make use of eyes closed and eyes open EEG, heart rate, skin conductance and clinical data in 34 PTSD pariticpants and matched controls. Data analysis RM anovas of spectral eeg regions, based on factor analyses. Univariate Anovas of SCR and HR Correlations between abnormal EEG regions, abnormal autonomic and clincal symptoms