Investigating cognitive function changes in patient of first episode psychosis by using a standard computer assist neuropsychological assessment battery, Integ Neuro.

Proposal details

Title: Investigating cognitive function changes in patient of first episode psychosis by using a standard computer assist neuropsychological assessment battery, Integ Neuro.
Research Area(s): Schizophrenia and Allied Psychoses
Background: Studies of neuropsychological functioning in schizophrenia and have indicated widespread deficits in most cognitive domains with specific deficits in attention/vigilance, memory and executive functions . These deficits have been noted to have a marked effect upon social functioning and outcome that are over and above the relationship seen with symptoms in the disorder . Recent research has shown that these are as severe in people with their first episode of schizophrenia as those with chronic schizophrenia. Similar findings were demonstrated in the group of first episode psychosis that patients had widespread of deficits in their cognitive functioning . Preliminary finding over a small sample of patients who have undergone re testing at 12 months (N=20) shows that there are 36% of patients improved and 55% deteriorated in their overall cognitive function tests performance over the year. Cognitive deficits are stable over time for both chronic schizophrenia and first episode schizophrenia . It has also been demonstrated in the fist episode psychosis patients that there is a trend of deterioration over a year 5. Over the short term, limited change in selective attention has been seen with amelioration of symptomatic state, particularly disorganisation . Over the longer term, little correlation has been noted between cognitive deficits and symptom pattern except with negative symptoms . The stability in the severity of cognitive deficits is stable, despite marked improvement in symptomatology with treatment with antipsychotic medication .
Aims: To investigate if there is any change of cognitive functioning of clients of the Early Psychosis Intervention program over a year.
Method: 1. Patients admitted to the Early Psychosis Intervention Program will be tested as soon as their mental state permits, with the computer assisted neuropsychological assessment battery, Integ Neuro. 2. Standard psychometric measurements: a. Positive and Negative Symptoms Scale (PANSS) b. Calgary Depression Scale c. Mania Rating Scale d. Auditory Hallucination Scale e. Delusion Scale d. Social Function Scale 3. The assessment, including Integ Neuro and the Standard psychometric measurements, will be repeated in 12 months. 4. Statistical analysis on a. if there is any significant relationship between symptoms rating and the Integ Neuro scoring before and after one year b. if there is any significant changes over one year in patients? cognitive function in their Integ Neuro scorings. c. Relationship between cognitive function and social function by using MANOVA