Identifying the ADHD signature: Cognitive and Brain Function Markers for standardized assessment

Proposal details

Title: Identifying the ADHD signature: Cognitive and Brain Function Markers for standardized assessment
Research Area(s): ADHD and Allied Conditions
Background: This Project is part of an Australia Research Council (ARC) Linkage Grant with The Brain Resource Company (Grant no. LP0349079). This paper is the first to feature the ADHD profile and supports the ADHD Reports.
Aims: Attention Deficit Hyperactivity Disorder (ADHD) is a common, neurodevelopmental psychiatric disorder, often allied with conduct, learning and emotion-related comorbidities. Both diagnosis and treatment of ADHD remain controversial, and there is a need for new objective assessment tools, complementing clinical information, in making diagnostic and treatment decisions. We used a standardized approach to identifying cognitive and brain function markers that define an ADHD signature at high levels of confidence and sensitivity.
Method: 175 ADHD children/adolescents and 175 matched healthy controls were tested on a comprehensive battery of cognitive (both general and social) tests, coupled with clinical histories. They were also tested on electroencephalogram (EEG) measures of brain arousal and cognitive task-related brain activity. A new method for standardizing scores across age and sex was employed. We identified the measures that differentiated ADHD at the highest confidence levels. The combination of these measures, which classified ADHD with the greatest sensitivity, was then determined