Misinterpreting Threat in ADHD: Evidence for a Neural Marker

Proposal details

Title: Misinterpreting Threat in ADHD: Evidence for a Neural Marker
Research Area(s): ADHD and Allied Conditions
Background: This Project is part of an Australia Research Council (ARC) Linkage Grant with The Brain Resource Company (Grant no. LP0349079).
Aims: In addition to cognition impairment, there are marked disruptions to mood and emotion processing in attention deficit hyperactivity disorder (ADHD), but little is known about the neural basis of these disturbances. We examined ADHD disturbances in mood and emotion recognition, and underlying neural systems. These disturbances were examined pre- and post-medication with stimulants.
Method: Participants were 51 unmedicated ADHD adolescents and 65 matched healthy controls, rated for depressed and anxious mood and recognition accuracy for facial expressions of basic emotion. Brain function was recorded using event-related potentials (ERPs) while subjects viewed these expressions. ADHD subjects were retested after four weeks, following treatment with methylphenidate (MPH).