General and social cognition in first episode schizophrenia: Equivalence with MATRICS domains and functional outcomes

Proposal details

Title: General and social cognition in first episode schizophrenia: Equivalence with MATRICS domains and functional outcomes
Research Area(s): Schizophrenia and Allied Psychoses
Background: It is recognized that both general and social cognition are important in predicting real world outcomes in schizophrenia, typically with greater consistency than positive symptoms. The MATRICS Consensus Cognition Battery (MCCB) is a paper-and-pencil test designed to assess 6 core domains of general cognition (Verbal Comprehension was dropped) and social cognition in schizophrenia studies and trials. Here, we assess general and social cognition for the first time in first episode schizophrenia using the computerized touch-screen battery IntegNeuro. We determine equivalence with MATRICS domains and prediction of functional outcome in terms of quality of life and social functioning.
Aims: 1. IntegNeuro will assess domains corresponding to those of MCCB. 2. Individuals with FES will show impairments on each domain of general and social cognition, and 3. these impairments (but not positive symptoms) will be associated with quality of life and social functioning.
Method: Individuals with first episode schizophrenia (n=56) and matched controls assessed on IntegNeuro, associated computerized DASS and EQ tests and ratings of quality of life and social functioning.