Resting EEG, extraversion, and COMT

Proposal details

Title: Resting EEG signatures of agentic extraversion AND the COMT VAL158MET POLYMORPHISM
Research Area(s): Individual Differences
Background: The COMT val158met polymorphism has been associated with extraversion [Reuter, M., & Hennig, J. (2005). Association of the functional catechol-O-methyltransferase VAL158MET polymorphism with the personality trait of extraversion. Neuroreport, 16(10), 1135-1138] and has also been shown to modulate the pharmacological effects of dopaminergic agents [Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., et al. (2003). Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy of Sciences, 100(10), 6186-6191] paralleling the modulatory effects we observed for agentic extraversion.
Aims: I propose to combine the already approved replication (and successful) of the association between extraversion and resting posterior versus anterior EEG theta activity (manuscript in preparation) with (1) a replication of the COMT-extraversion association and (2) a test of the new hypothesis of an association between extraversion and posterior versus anterior EEG theta as a resting EEG endophenotype. Combining these analyses in a single publication is likely to attract considerably more interest.
Method: