BMI and DTI

Proposal details

Title: The association of body mass index (BMI) to cognitive function and neural connectivity
Research Area(s): Brain Imaging
Thinking and Cognition
Background: Obesity has been established as an independent risk factor for poor neurocognitive outcome. Our previous work with BRID data showed that obese individuals had smaller whole brain and total greater matter volume. However, no study has examined the association between obesity and DTI indices like fractional anisotropy (FA). A reduction in neural connectivity (i.e. lower FA) seems likely given the obeserved deficits in attention and executive function in this population.
Aims: We propose to determine whether: 1. Increased BMI is associated with reduced FA in frontal and temporal regions 2. FA values moderate the association between BMI and reduced cognitive function
Method: Archival data from the BRID will be used