Alzheimer's and WMH

Proposal details

Title: White matter hyperintensities and Alzheimer disease
Research Area(s): Brain Imaging
Thinking and Cognition
Background: White matter hyperintensities are areas of increased lucency visualized on T2-weighted MRI scans. These areas are thought to reflect small vessel cerebrovascular disease and are related to cognitive abilities in older adults. Recent literature has supported a specific role of WMH in Alzheimer's disease, and although a non-specific marker, examination of the distribution of WMH may help further elucidate mechanisms linking them to Alzheimer's disease.
Aims: This project seeks to examine the regional distribution of WMH in patients with AD and controls and to examine cognitive correlates
Method: We will compare lobar distribution of WMH between AD patients and contorls and examine relationships with cognition.