The neurophysiological underpinnings of specific psychotic symptoms in people with first episode psychosis

Proposal details

Title: Investigating the neurophysiological underpinnings of specific psychotic symptoms in people with first episode psychosis
Research Area(s): Schizophrenia and Allied Psychoses
Background: Neurophysiological studies of schizophrenia and related psychoses typically group people with vastly different clinical profiles into a 'patient' group and compare thir neurophysiology to a matched group of healthy controls. Very little is known about the neurophysiological bases of specific psychotic symptoms, and it is quite feasible that the different psychotic symptoms have unique neurophysiological bases.
Aims: To investigate the neurophysiological underpinnings of specific psychotic symptoms in people with first-episode psychosis.
Method: To compare the neurophysiology (specifically, resting EEG, auditory evoked potential data and structural MR data) of: 1) FEP patients with a history of a given psychotic symptom (e.g. auditory hallucinations, delusions of control), 2) FEP patients without a history of the given psychotic symptom, and 3) matched healthy controls.