high-risk individuals and first-episode schizophrenia

Proposal details

Title: The difference between high-risk individuals and first-episode schizophrenia
Research Area(s): Brain Modeling
Schizophrenia and Allied Psychoses
Brain Imaging
Individual Differences
Background: Schizotypy(or SPD) provides important insights into the origins of schizophrenia. Individuals who meet the diagnostic criteria for SPD in young adulthood are at a heightened risk for developing schizophrenia. A 15-year follow-up clinical study reported a conversion rate of 40%. Of children with schizotypal-like diagnoses at age 10 years, 7.6% received a diagnosis of schizophrenia by age 27.The rates of conversion from adolescent SPD to schizophrenia have been estimated in 20%–40%. Therefore, not all SPDs develop to schizophrenia. The study will investigate the differences between those individuals with high schizotypal scores and patients of first-episode schizophrenia. The study will help identify those protective factors and risk factors in the breakdown from SPD to schizophrenia.
Aims: #1: individuals with high schizotypal scores show abnormalities in cognitive and EEG measures, the abnormalities are at a moderate level, compared to patients with schizophrenia. #2: major cognitive differences between two groups are associated with frontal lobe and limbic system.
Method: Compare two groups on EEG measures, cognitive measures, and fMRI data.