Obesity and neurocognitive outcomes

Proposal details

Title: Influence of genetic markers on cognitive function and brain MRI in obesity
Research Area(s): Brain Imaging
Thinking and Cognition
Genetics
Background: Work from our lab and others demonstrates that obesity is associated with adverse neurocognitive outcomes, including greater risk for Alzheimer's disease and accelerated cognitive decline. However, these studies also reveal substantial variability in these outcomes, suggesting the likely role of an obesity X genetic marker interaction. The proposed study would examine the possible interaction between body mass index (BMI) and genotypes for APOE and BDNF on cognitive function and MRI indices. No study has examined this possibiity, despite the known influence of APOE and BDNF on both weight and neurocognitive variables.
Aims: 1. Determine the possible interaction between BMI and APOE genotype on cognitive function and MRI indices across the adult lifespan. 2. Determine the possible interaction between BMI and BDNF genotype on cognitive function and MRI indices across the adult lifespan.
Method: Archival data from healthy participants in the Brain Resource International Database will be analyzed for these possible interactions.