Deficits in P300 associated with first-episode schizophrenia

Proposal details

Title: Deficits in P300 associated with first-episode schizophrenia: Amplitude and latency
Research Area(s):
Background: Selective attention is taken to represent the ability to direct attentional resources to aspects of a complex stimulus and to maintain such attentiveness over time. In EEG research, selective attention is represented by the ERP P300 evoked during an auditory or visual oddball task. In schizophrenia, studies have consistently reported P300 deficits, leading to the proposal that P300 be regarded as a biomarker for schizophrenia. However, while there is good evidence for reduced P300 amplitude (reflecting amount of attention), the finding of increased latency (reflecting speed of stimulus classification) has been variable. A recent meta-analysis of auditory P300 in first-episode schizophrenia (Qiu, Tang, Chan, Sun, & He, 2014) found both amplitude and latency deficits in first-episode schizophrenia, but also identified task difficulty as a significant moderator of heterogeneity, particularly affecting P300 latency. Further studies in this area are required to elucidate the latency deficit in schizophrenia in association with the expected amplitude deficit.
Aims: The proposed study aims to investigate the impact of psychosis on the cortical electrical brain function associated with selective attention, specifically examining P300 latency and amplitude.