Genetics

Genetics

MolecularNeuroâ„¢ Collection via cheek swab or saliva method (and in some cases bloods) of DNA for extraction of SNPs and other variants of interest which impact the brain.

SNPs currently available are listed below. A further 300 SNPs are due to be completed by October 2009 (including neuregulin and genes shown to impact synaptic and hormonal function)*

Data Available:

First 20 SNPs are:

  • Apolipoprotein E, APOE
  • Abnormal spindle-like, microcephaly-associated (A44871G – refers to genomic DNA sequence; amino acid change is S2562G), ASPM Brain derived neurotrophic factor (val66met), BDNF
  • Cathepsin D (224C>T) (A58V), CTSD
  • Catechol-O-methyltransferase (val108/158met), COMT
  • Dopamine receptor type D2 (-141C Ins/Del), DRD2_1
  • Dopamine receptor type D2 (957C>T), DRD2_2
  • Dopamine receptor D4 (-521C>T), DRD4_2
  • Dopamine beta hydroxylase (-1021C>T), DBH
  • Dopamine transporter (40-bp VNTR), DAT1
  • Dopamine D4 receptor (48-bp VNTR), DRD4
  • Histamine N-methyltransferase (314C>T), HNMT
  • Microcephalin (G37995C – refers to genomic DNA sequence; amino-acid change is D219H), MCPH1
  • Monoamine oxidase A (30-bp VNTR), MAOA
  • Serotonin receptor 1A (-1019C>G), HTR1A
  • Serotonin receptor 2A (-1483A>G), HTR2A_1
  • Serotonin receptor 2A (H452Y), HTR2A_2
  • Serotonin receptor 3A (C178T), HTR3A
  • Serotonin transporter (44-bp DIP), 5HTT
  • Succinate-semialdehyde dehydrogenase (538C>T) (H180Y), ALDH5A1

* Contact BRAINnet@brainnet.net for further information on these additional SNPsong>Data Available:

First 20 SNPs are:

  • Apolipoprotein E, APOE
  • Abnormal spindle-like, microcephaly-associated (A44871G – refers to genomic DNA sequence; amino acid change is S2562G), ASPM Brain derived neurotrophic factor (val66met), BDNF
  • Cathepsin D (224C>T) (A58V), CTSD
  • Catechol-O-methyltransferase (val108/158met), COMT
  • Dopamine receptor type D2 (-141C Ins/Del), DRD2_1
  • Dopamine receptor type D2 (957C>T), DRD2_2
  • Dopamine receptor D4 (-521C>T), DRD4_2
  • Dopamine beta hydroxylase (-1021C>T), DBH
  • Dopamine transporter (40-bp VNTR), DAT1
  • Dopamine D4 receptor (48-bp VNTR), DRD4
  • Histamine N-methyltransferase (314C>T), HNMT
  • Microcephalin (G37995C – refers to genomic DNA sequence; amino-acid change is D219H), MCPH1
  • Monoamine oxidase A (30-bp VNTR), MAOA
  • Serotonin receptor 1A (-1019C>G), HTR1A
  • Serotonin receptor 2A (-1483A>G), HTR2A_1
  • Serotonin receptor 2A (H452Y), HTR2A_2
  • Serotonin receptor 3A (C178T), HTR3A
  • Serotonin transporter (44-bp DIP), 5HTT
  • Succinate-semialdehyde dehydrogenase (538C>T) (H180Y), ALDH5A1

* Contact BRAINnet@brainnet.net for further information on these additional SNPs