Best Noopept Stack: Better Focus, Creativity & Mood

Best Noopept Stacks

Known as the fastest cognitive enhancement supplement, no one who has ever heard of Noopept stack would refuse to try this popular nootropic.

It has shown longer-lasting and powerful effects like heightened focus, improved mood, and creativity as a sole nootropic supplement.  

And so just think about stacking Noopept with other nootropic supplements. This will not only enhance the effects and increase the cognitive ability, but also give you a competitive edge over others.   

The Noopept stack for better focus, creativity, and mood is commonly seen in both students and the workplace.

However, if you are new to nootropics, or trying to stack nootropics, then this guide will help you experiment, and take you through the 4 best Noopept Stacks that you can try.      

Benefits & How Noopept Works

Noopept is a type of neuropeptide, found in the human body in the form of cycloprolyglycine. The synthetic drug goes by the formula N-phenyl acetyl-L-polyglycine and belongs to the class of Racetams.

It is referred to as a smart drug due to its anti-psychotic, anti-depressant, and anxiolytic properties [1].  

It is known to enhance memory and learning ability. It gives the user a better ability to focus and process the information.

Various studies showed taking Noopept reduced depression and improved mood in the subject participants [2]. The Noopept users also showed greater ability in logical reasoning with heightened creativity, focus and mental clarity.

In addition to its cognitive benefits, some additional benefits include –

  • Alleviates stress
  • Prevents neurodegenerative diseases like Alzheimer’s, Parkinson and Schizophrenia.
  • Reduce stress associated memory loss
  • Boost intelligence and increase perpetual awareness.
  • Noopept increases brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF).

As you consume the Noopept stack, it reaches the maximum concentration within 15 to 20 minutes. It increases the uptake of oxygen and glucose in brain cells as it travels the blood brain barrier immediately.

It targets the glutamate receptor cells that are vital for learning, memory and focus. It prevents the degradation of glutamate by biding to the neurotransmitter acetylcholine. Thus the glutamate-related cognitive abilities are enhanced like mental alertness, memory, focus, and creativity.

Noopept also influences the levels of nerve growth factor and brain-derived neurotrophic factor in the hippocampus. Both the neurotrophins are required for maintaining healthy neurons [3] and cognitive benefits.

These were the major mechanisms of action that make Noopept an effective and powerful nootropic with instantaneous effects.  

Noopept Dosage & Interactions

Noopept is known to have high potency, and so it is recommended to take it in low doses. Its active ingredients have soluble properties that make it rapidly absorbed by the brain.

A typical recommended dosage of the Noopept stack is 10mg to 40mg, thrice a day. Small doses taken multiple times ensures maximum benefit rather than a single large dose. This will help you prevent adverse effects like headaches, irritability, dizziness and restlessness.

For optimal brain performance and cognitive performance, ensure you follow the correct dosage and administration. You can start with a small dose and then slowly work up the dosage to know what amount is right for you.

Also, as our body builds up tolerance of Noopept prolonged use of the supplement is not recommended. Its short half-life is one downside of Noopept nootropic that makes it less by some users.

The Noopept dosage is advised for about 45 days to 3 months, followed by a month’s break and then restarting with the next cycle.    

The 4 Best Noopept Stacks

The nootropic supplements offer various benefits and stacking them together synergizes their different pathways to give you the additional benefits.

Yes, you can easily combine Noopept with other different nootropics to optimize the total effect.

Confused about what is the best Noopept stack, then keep reading.  

Focus & Concentration Stack

The best Noopept stack for students boosts their memory and recall function, along with the enhancement and enhances their concentration, attention, focus, and motivation.

A combination of racetams with choline supplements is recommended to maximize the effects of the different nootropics stack on focus and concentration.  

Piracetam and Alpha GPC

Noopept has properties similar to Piracetam, as both of them belong to the Racetam family. As their mechanism of action is the same, using the two supplements together can enhance their effects on our brain functions. It acts on the glutamate neurotransmitters, and result in improved memory and cognition [4].

The synergy between the two racetams is enhanced and energized with the addition of Alpha GPC like choline supplements. It counteracts on the side effects like headaches, thus improving your mood.

Huperzine A

Huperzine A acts as an acetylcholinesterase inhibitor and indirectly supports and enhances the activity of Noopept.

It is an herbal supplement that prevents the breakdown of extracellular acetylcholine form. However, do not take more than 50mcg as it is powerful and can cause adverse side effects.  

Creativity Stack – Sulbutiamine and Aniracetam

The next combination of supplements is called the creativity stack. It is also known to elevate your imagination and mood, reducing anxiety. It is recommended especially for those people who need a powerful brain boost.

Aniracetam and sulbutiamine enhance the effects of Noopept. While Sulbutiamine, a derivative of Vitamin B, enhances memory function, Aniracetam acts as an anxiety reducer. They together calm you psychologically and mentally and keep you relaxed.

And so your creativity will flow naturally.     

Mood Enhancement Stack – Aniracetam

Aniracetam is one of the foundation supplements of almost all the nootropic stacks. You can combine it with all sorts of nootropics including Noopept.

This combination is preferred if you want to reduce anxiety and elevate your mood in addition to improving the cognitive brain functions [5].

Working in a highly competitive and stressful environment, this stack will help you stay focused and perform better. Noopept and Aniracetam together ensure better cognitive function, social fluidity, memory and mood.     

Memory & Learning Ability Stack – Alpha GPC

The Noopept and Alpha GPC stack is known to be effective in improving the memory and learning ability of individuals.

It is a choline supplement that boosts the synergy of the main nootropic ingredient. Learning involves the creation of new memories and the Noopept stack improves the process of collecting the sensory information and memory formation.

Noopept and Alpha GPC is thus a very potent nootropic with a great capacity to enhance memory and learning ability [6].

How to Design Your Noopept Stacks?

Nootropic is undoubtedly a popular, trusted and effective option as a cognitive function enhancing supplement. You can even combine two or more nootropics and customize a stack of your own.

However, you need to perform extensive research before you start choosing the nootropic supplements. According to the needs of your body, you should stack your supplements.

Before adding up these cognitive enhancers, think of the goals and accomplishments you want to achieve. In addition to why you want to take it, make sure you buy Noopept and other brain boosting drugs from a trusted source.

Answers to these questions will help you sort the family or class of nootropics that is right for you. You can choose from the two options –

First, you can select a supplement from the Racetam family-like Piracetam, Aniracetam Pramiracetam or Oxiracetam. They have positive effects like improved memory function and cognition. It supports the Noopept smart drug and maximizes its effects.

The second option includes unrelated ingredients including preformulated supplements like Mind Lab Pro with a wide range of benefits. It not only enhances the effects of Noopept but also reduces the side effects.       

The perfect stack can only be created with experimentation and on a trial basis. To identify your base guide and goals in mind and then start with small doses. There is no exact dose known, as everybody reacts differently does not go out of the recommended dose.

For instance, L Theanine is an amino acid known to reduce stress and mental fatigue. It does not have different mechanisms of action than Noopept, so they work together to create a fantastic effect.  

Noopept Stacks Cycle

Have you thought of cycling your Nootropics stack? Is it a good idea?

Yes, as our body is adaptive and can build tolerance it is always advised to cycle Noopept stack.

By Noopept stack cycle we mean taking nootropics supplements for some days straight and then taking a break.

It prevents our body from getting used to the consumption of Noopept. You can take the drug for a week, and then continue for 3 to 4 days after by taking a break of 5-6 days in between.  

Also, make changes in this routine so that your body doesn’t adjust to this cycle as well. Do not let your body adapt to Noopept stack.


Noopept is an effective, powerful, and potent nootropic, however, stacking it with other supplements synergizes its effects and maximizes its cognitive benefits.

The various nootropic ingredients might have their own particular purpose, but you need to select them carefully.

Noopept is an amazing nootropic that can be used alone as well as in combination with other smart drugs. But be sure to take it in the recommended dose.

We have tried to cover the best Noopept stacks that you can customize. We hope this guide was helpful to get you started with stacking nootropics together.   

Do share your views on your best stack and which stack works for you.


  1. Vasileva, E., Abdullina, A., Kondrakhin, E., & Kovalev, G. (2018). Antidepressant-like activity of cyclo-l-prolylglycine. European Neuropsychopharmacology, 29:S544-S545.
  2. Uyanaev, A., & Fisenko, V. (2006). Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis. Bulletin of Experimental Biology and Medicine, 142(2):202-204.
  3. Ostrovskaya, R., Gudasheva, T., Zaplina, A., Vahitova, J., Salimgareeva, M., Jamidanov, R., & Seredenin, S. (2008). Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bulletin of Experimental Biology and Medicine, 146(3):334-337.
  4. Neznamov, G., & Teleshova, E. (2009). Comparative studies of noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neuroscience and Behavioral Physiology, 39(3):311-321.
  5. Knapp, R., Goldenberg, R., Shuck, C., Cecil, A., Watkins, J., et al. (2002). Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. European Journal of Pharmacology. 440(1):27-35.
  6. Schettini, G., Ventra, C., Florio, T., et al. (1992). Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats. Pharmacology, Biochemistry, and Behavior, 43(1):139-51.
Erica Bail

Having specialized as a Neurologist for 8+ years treating patients with diseases like Parkinson's disease, Sclerosis, Dementia and Brain Injury. Dr Erica has the passion and experience to detect, diagnose and manage any type of brain disorder.

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