11 Best Nootropics For Energy (Natural & Synthetic)

Nootropics For Energy

To accomplish your goals and keep up with your fast-paced life, mental health is equally important as physical health.

While diet and exercise ensure your physical fitness, the nootropics help you develop robust brain energy. 

These cognitive enhancers are known to increase mental energy and tap on the focus, fast mental processing, memory, active thinking and overall brain health.

They are proven to be a healthier choice to boost your brain energy, cognitive performance and productivity. These brain supplements ensure energized cognition drive throughout the day.

But which nootropic is best for mental energy?

Numerous nootropics are replacing the energy shots and drinks from the market and so choosing one energy-boosting nootropic can be difficult.

But do not worry as today we will be sharing the 11 best Nootropics for energy, including both natural and synthetic nootropics that you can try.

Do Nootropics give you energy?

Nootropics or brain boosters are natural or synthetic substances tagged with compounds that are responsible for the enhancement of mental energy and functions like memory, creativity, and mental performance [1].

Chief investigation on nootropics carried out in the context of energy metabolism supports their role as energy boosters [1][2].

How Nootropics Energize the Brain?

The neurons depend on a continuous supply of nutrients and oxygen that our brain uses to turn down glucose and amino acids to generate energy. And as Nootropics are introduced into the system, blood circulation to the brain increases. Also, the nutrients, oxygen, and energy flow to the brain increase [1].

Optimizing Mitochondrial Efficiency

Mitochondria, the powerhouse of the cell, creates ATP required for various metabolic activities like cognitive functions. Nootropics maintain mitochondrial productivity and efficiency.

Enhancing Neurotransmitter Status

Nootropics balance the inhibitory and excitatory neurotransmissions to optimize brain chemicals for better brain energy. This reinforces a healthier sleep-wake cycle which is important to achieve better energy and peak mental performance.

Bolstering Stress Resistance

The cognitive functions are boosted with good stress resistance, along with the enhancement of focus, memory, and concentration. 

Supporting Blood Flow to the Brain

Cerebral circulation is also known to boost brain energy. Nootropics ensure healthy blood flow to the brain and boost bio-pathway that revitalize low energy levels of the brain by the brain cells. .

What are the Best Nootropics for Energy?

Nootropic compounds work on your mental functions including motivation, memory, concentration, and energy. In addition to their help in blood circulation, they also act as energy boosters.

There are two different kinds of energy nootropics available- synthetic which is created in the lab and the natural and herbal kind [1].

Here are a few smart drugs that optimize brain energy and enhance your brain function.

Natural Nootropics

The natural nootropics that give you energy affect the dopamine neurotransmitters, thus enhancing your alertness and energy [3]. Some of the natural nootropics are-


Citicoline or CDP Choline is an essential nutrient that increases the level of neurotransmitters and has proven neuroprotective effects [4].

It is an extremely important nootropic that has the ability to boost brain energy and performance [5].

Research has proved that Citicoline effectively enhances energy levels as it works to increase the energy reserves and its utilization with age [6].

It has also shown desirable results in increasing memory, focus and concentration, alongside improving your mood [5]. Thus citicoline supplementation is considered a powerful nootropic for energy and focus.

Rhodiola Rosea

Rhodiola Rosea is a powerful plant that has been used as a natural stress reliever for centuries.

Various clinical trials have confirmed its action against mental fatigue, and improvement in cognitive function and mood [7]. 

Mild use of Rhodiola moderates anxiety and depression [7], increases energy metabolites, and thus improves energy production in the brain [8].

R. rosea is a potent energy nootropic as it maintains high energy reserves to manage energy during stress [8].


The best natural nootropic stack for energy is incomplete without caffeine. Cola, tea and coffee containing caffeine work both as a nootropic and energy drink.

Caffeine is a popular central nervous system stimulant. It increases energy metabolism throughout your brain by activating the nor-adrenaline neuron and the release of dopamine. Studies have proved the effectiveness of caffeine against fatigue and drowsiness [9].

It even improves the reaction time, wakefulness, motor coordination, and concentration [10].  


Acetyl-L-Carnitine (ALC) is a naturally occurring substance that is synthesized in the human brain, kidney and liver [11].

ALC reduces depression and increases energy and wellness thus improving the quality of life [12]. 

ALC can also cross the blood-brain barrier and has been proposed as the treatment of degenerative diseases like Alzheimer’s. Acetyl-L-Carnitine is one incredible energy-boosting nootropic that also improves cognitive function, both learning and memory [11].  


Curcumin, an active turmeric component, is known for its powerful antioxidant properties. This plant-based compound has cognitive benefits infused in it [13]. 

Its potential neuroprotective property protects you from free radicals and inflammation. It promotes a good mood and healthy cognitive function.

According to research Curcumin even reduces oxidative stress and decreases inflammation [15]. It supports the production of DHA important for brain cell production, health, and development [14].

This brain-boosting supplement also boosts neurogenesis and brain function.


L-Theanine is considered to be neuroprotective, in addition to being a mild sedative. It acts as a brain-stimulating neurotransmitter, calming the overactive thoughts, reducing the symptoms of anxiety and is mildly euphoric [16].

Studies have proved that its beneficial physiological effects like promoting relaxation, concentration and learning ability [17].

L-Theanine is found exclusively in tea and can cross the blood-brain barrier and enhances the accuracy of information processing, and treatment of mental fatigue and tiredness [18].

Synthetic Nootropics

Apart from natural nootropics, synthetic supplements also contain active ingredients that are powerful stimulants and enhance memory. Some synthetically produced energy nootropics are-  


Modafinil is an FDA-approved nootropic supplement that is widely used for cognitive enhancement. Basic studies show intake of modafinil enhances executive function, and improvement in their learning, attention and memory to some extent [19].

It is studied that Modafinil also improves wakefulness in patients suffering from narcolepsy-like excessive sleepiness conditions along with attention and energy [20].

This nootropic also reduces reaction time and fatigue, thus enhancing your alertness, focus mood, and on the whole your cognitive performance [19].


Noopept is a known nootropic stimulant and has anxiolytic action. It influences the memory consolidation and retrieval process during each stage.

The action of the drug is based on its anti-inflammatory and anti-oxidant effect that inhibits neurotoxicity [21].

Various researches on Noopept suggest that it has anti-diabetic properties as well [22].

Noopept has also shown modulating effects with nootropic and neuroprotective properties [23].

Mind Lab Pro

Mind Lab Pro is a nootropic that acts as a brain booster and hikes the performance of your brain. The careful ingredients selection of Mind Lab Pro creates brain energy, boosts memory and rate of neurotransmitter choline [24].

The Pine Bark Extract in its formulation releases nitric oxide that relaxes blood vessels and promotes the flow of blood to the brain and body [25].

Also, its brain stimulation property acts as a key to develop problem-solving skills, and optimum learning [26].


Another best nootropics for energy and motivation is Phenylpiracetam. It is an analog of the first-ever nootropic, Piracetam.

Phenylpiracetam has various benefits with zero side effects. It improves your motivation, focus, learning, memory, mood, and anxiety levels. It is also known to be effective in improving both physical and mental performance. However, it is banned from being used in sports [27]. 


Sulbutiamine, a derivative of Vitamin B1 (thiamine) is important for cognitive functions and good memory.

According to a study, chronic administration of sulbutiamine showed improvement in memory formation and improved brain performance [28].

It improves our energy levels, concentration, memory, and mood as it works on the glutamine, glutamatergic and cholinergic receptors [29].

How Nootropics Improve Short-Term Memory?

Short term Memory is the small amount of information that is available readily but for a small period of time. And nootropics can enhance cognition including short-term memory. 

Nootropics are stacked with choline sources that are known for optimal memory-boosting results. It increases cognitive functions and improves short-term memory. Bacopa Monnieri, Vitamin B6, and Piracetam, Citicoline are popular memory enhancers.

Bacopa Monnieri addresses memory by altering the serotonin levels in the brain. It is a potent nootropic that helps to deal with high stress and promote relaxation, improve memory and mental processing speed [31].

Vitamin B6 aids in myelin sheath formation that makes communication between neurons smooth and improves your memory. It is also involved in the maintenance of healthy neurons, promoting memory functions.

Piracetam affects the acetylcholine receptors and in turn, plays a vital role in learning and short term memory. Also, citicoline drug administration prevents negative interactions and stress and enhances short term memory [33].      

Nootropics Side Effects

Even though nootropics are packed with benefits, their misuse can cause severe problems. These supplements are known to enhance mental and cognitive abilities. These agents can alter, improve or boost memory potential, concentration, and cognitive functioning.

The possible side effects observed on over-usage or misuse of nootropic for physical and mental energy include –

  • Diarrhea
  • Gastrointestinal discomfort
  • Insomnia
  • Headache
  • Restlessness
  • Fatigue

These are the likely side effects [30]. However, the best nootropics for mental energy are formulated in the right concentrations and so until you are taking it in the prescribed amount it will have no side effects.  

What is the strongest nootropic?

According to the data reported and literature available, cholinergic has proved to be effective against memory and attention deficits.

From the above nootropic stack for energy, we pick Mind Lab Pro to be one of the best and effective for high energy. Packed with Phosphatidylserine and Maritime Pine Bark extract in amounts required for enhancing the energy in neurons, Mind Pro Lab is the strongest nootropic.


Now you do not need to suffer from chronic fatigue, brain fog or loss of memory or concentration. You can be a bundle of energy every day, by incorporating nootropic supplements into your daily routine.

Nootropic supplements support cognitive vitality, treat chronic fatigue, improve mood and mental capacity of individuals. 

It gives you the boost and acceleration which is much needed to go through the day.

Optimized energy levels, focus, memory, and alertness are some promising mental benefits of the nootropics available today in the market. However, ensure that you know which cognitive enhancer is best for you.


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Erica Bail

Having specialized as a Neurologist for 8+ years treating patients with diseases like Parkinson's disease, Sclerosis, Dementia and Brain Injury. Dr Erica has the passion and experience to detect, diagnose and manage any type of brain disorder.

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