12 Best Nootropics for Motivation – Wake Up Focused with Endless Energy

best nootropics

Staying motivated all the time is not easy.

Lack of motivation is one of the various excuses that we give every day for being stuck in a career, relationship, or lifestyle.

If you are also struggling with an inner drive to give your peak performance, then nootropics for motivation can help you.

The nootropic supplements play with your brain chemicals like dopamine to promote better drive.

Neuroscience suggests that dopamine levels control how we feel and increase our motivation level and motivation nootropics do just that. They are efficient, effective with no severe withdrawal symptoms.

In this guide, we will be discussing the 12 best nootropics for motivation that will help you maintain healthy dopamine levels.

The Neuroscience of Motivation

Motivation is the energizing behavior of an organism or individual in pursuit of a goal. It is the primary element of our interaction with each other and the world. The motivational drive thus is modulated by both internal states as well as environmental conditions [1].

Studies have shown higher dopamine levels in highly motivated people [2]. On the other, low dopamine levels indicate low energy levels , along with low motivation, depression, compulsive and impulsive behaviors, and poor learning and memory.

When we indulge in learning new activities or trying something new for the first time, solving problems, or exploring something challenging, the dopamine level in our body increases [3].

It regulates motivation and gives us the perseverance and initiative to go after the work that is important.

Lack of motivation can be seen in individuals suffering from ADHD, Alzheimer and Parkinson’s disease.

And since nootropics’ key target of intervention is the dopamine neurotransmitters, individuals respond to these supplements well.  

How Does Dopamine Affect Motivation?

Researchers have shown that dopamine neurotransmitter affects pleasure and reward. A dip in its level causes a lack of motivation and zeal to take initiative and do things [4].

The latest scientific evidence suggests that the dopamine neurotransmitter acts before we do our work. It encourages us to act. Dopamine is released either to avoid something bad or achieve something good.

Dopamine takes different pathways to influence our well-being and motivation. It is called the reward pathway of motivation. The dopamine pathway is activated by glutamatergic signaling [3].

While a lot of people equate dopamine with pleasure, it is actually the want of the individual for the reward. At the same time, excess dopamine is also harmful.

And this is when nootropics come into action. They enhance dopamine levels and maintain them to increase your motivation and internal drive.    

The Best Nootropics for Motivation

You can supplement your nootropics stack with energy promoting and dopamine boosting products. They are an effective way to enhance cognitive abilities and restore and enhance motivation levels.

We have got you the top 12 nootropic stack for motivation packed with high-quality analytically tested ingredients.

1. Tyrosine

To increase your dopamine level the one thing you need the most is its amino acid precursor Tyrosine and so it tops our list of nootropics for motivation.


Tyrosine is a non-essential amino acid, and it gets easily available to our body from common food. It is also a pre-cursor for nor-adrenaline which enhances motivation.   

The L-Tyrosine is converted to L-DOPA, which is then converted into dopamine [5].

However, during stress and times of pressure condition, our body cannot synthesize tyrosine. And so we need to replenish the tyrosine store. You can supplement your diet with Tyrosine, or its derivative N-acetyl Tyrosine to increase dopamine levels and enhance creativity and motivation.  

  • Prominent ingredient of workout supplements like fat burners
  • It increases dopamine levels, thus increasing motivation.
  • Enhance creativity and allows smooth flow of ideas.

2. TeaCrine® (Theacrine)

TeaCrine is a new addition for nootropic users but is becoming their personal favorite. It is being used by people for its function of providing long-lasting focus and energy without side effects like anxiety, jitters, and other crashes that come with stimulants. You can try these nootropic supplements for anxiety.

TeaCrine (Theacrine)

It is a naturally occurring, pure alkaloid found in robusta coffee beans and Kucha tea and takes care of your mental energy [6]. Studies have proved that Theacrine enhances dopamine levels and regulates other neurotransmitters.

TeaCrine is a valuable antioxidant that boosts your motivation and all-day energy. And the best part is that it doesn’t impact your cardiovascular system, and still ensures an increased level of energy, alertness, and motivation.

It is a milder and longer-lasting caffeine version, with zero tolerance build-up.   

  • It is an effective anti-oxidant.
  • Unlike Caffeine it delivers cognitive benefits without affecting the cardiovascular system.
  • It stimulates the brain by regulating various neurotransmitters like adenosine and dopamine.  

3. Dynamine® (Methylliberine)

Just like Theacrine, Dynamine also has neuro-energetic effects. Dynamine is the patented form of Methylliberine which has short-lasting but faster and milder effects on your focus, energy, and motivation [7].

Dynamine  (Methylliberine)

It is also a purine alkaloid isolated from the plant of coffee Robusta and Kucha tea leaf [8].

It gives you the right motivation when you don’t want sleep to interfere, for example ahead of a gym session or an important class or group studying.

Dynamine works by activating the dopamine receptor and inhibiting adenosine. As a result not only our motivation level is enhanced, but the tolerance build-up for Dynamine is also less.

It is a well-known supplementation used in the Sports industry, which acts fast and ensures a clean and smooth focus with overall enhanced mood, focus, energy, and motivation.    

  • Effects of Dynamine are hard-hitting and faster acting.
  • Activates dopamine and inhibits adenosine which causes less tolerance buildup.
  • It shows a synergistic effect with caffeine.  

4. Theobromine

Theobromine is a purine alkaloid found in cocoa-based products like chocolate and coffee. Studies have shown that it improves the mood and cognition functions of individuals and hence it is a popular ingredient of various drugs [9].


Very little information is known about this xanthine, however, it is known to promote alertness, motivation, and wakefulness.

It acts synergistically with caffeine and shows positive effects on cognition, mood, and even blood pressure.

The bitter taste of dark chocolate is due to the white crystalline theobromine powder. It also has a milder and long-lasting effect on our energy, giving a sense of euphoria and motivation to feel good and do better.

  • Majorly found in chocolate, giving it a bitter taste.
  • Promotes good respiratory health and enhances energy and motivation.
  • Cause a few side effects like headache and nausea.

5. Adrafinil

The next drug on our list of best nootropics for motivation that you can try is Adrafinil. It is a prodrug of Modafinil. Once you ingest the supplement, the concentration of modafinil in your body increases.


It heightens alertness and wakefulness. It is a prescribed, motivation-boosting drug that is commonly found as Provigil. It modulates the level of dopamine and adenosine, thus affecting the basic motivational state [10].

Professionals like nurses, or shift workers, or truck drivers who need to stay alert and focused can add Adrafinil to their nootropic stack.

It is also known for motivating individuals, boosting their productivity, and fighting hyperactivity and sleepiness. Its correct dose has shown improvement in short-term memory, but more clinical trials information is required to confirm the effect.

  • Adrafinil works by converting into Modafinil in the body.
  • Sold as an OTC supplement.
  • It is a prescribed wakefulness-promoting drug.

6. Uridine

We all know of uridine as a nucleotide that our body produces naturally. However, we can also take it in the form of a supplement as uridine monophosphate. In addition to enhanced memory and energy, it is known to boost your motivation, decrease anxiety and enhance your mood.


According to research, supplements with dietary uridine enhance cognitive functions and improve learning and memory [11].

Clinical evidence suggests a boost of cognition functions, mood, and motivation, along with anti-neurodegenerative and neurogenesis properties.

Its primary function is to modulate dopamine receptors that have an effect on motivation and mood-related features.

Uridine is commonly used in combination with fish oil and CDP-choline. It is called the Happy Stack that has shown significant enhancement in learning, memory, mood, focus, and energy.   

  • Boosting of mood, motivation, and cognition has been clinically proved.
  • It modulates dopamine receptors that act on our mood and motivation.
  • It is a part of the famous Mr. Happy nootropic stack.

7. Aniracetam

The next supplement is Aniracetam, from the Racetam family. It acts as both a stimulant and enhancer.

Aniracetam is a positive modulator of AMPA receptors and makes sure that you are alert and awake [12]. A lipid-soluble nootropic substance, Aniracetam is believed to be more potent than Piracetam.


It also increases the serotonin and dopamine levels in the pre-frontal cortex which explains its anxiolytic and anti-depressant effect. Aniracetam is a powerful supplement to boost motivation, mental energy, and create a flow of creative thoughts.  

It works like caffeine and treats depression, anxiety, and dementia without any side effects or withdrawal symptoms.  

  • It boosts our mental fluidity and flow of creative ideas.
  • It is known to have both anxiolytic and anti-depressant properties.
  • Studies have shown it to be well-tolerated.

8. Fasoracetam

Fasoracetam was graded as a research chemical, with nootropic effects like the ability to enhance and improve memory, mood, and focus and decrease anxiety.


Al these cognitive benefits, affect the way we feel and motivate us to uptake or complete the assigned work.    

Regular ingestion of Fasoracetam has shown up-regulation of the GABA receptors, which explains its anti-depressant and anti-anxiety properties [13].

It is a safe, effective, and efficient nootropic for motivation when a reasonable dosage is taken for a short period of time.

  • It is a popularly known anxiety-reducing nootropic.
  • It plays a protective role in neurodegenerative diseases.
  • Fasoracetam has also shown positive effects on people with ADHD disorder.

9. Noopept

One of the most popular nootropics that are found in almost every stack is Noopept. And the main reason behind its popularity is its wide range of cognitive benefits and suitability for most people.

Similar in its function to Piracetam, Noopept shows a great effect on your motivation, mood, focus, and memory in only a small dose.


According to clinical studies, Noopept increases the expression of growth factors like NGF and BDNF and stimulates the production of dopamine and serotonin which are involved in the enhancement of mood, logical thinking, memory, and motivation [14].

It also augments the alpha and beta waves of your brain, which makes you calmer and creative. You become motivated to make innovative, resourceful, and right decisions.

  • It has powerful cognition-enhancing benefits.
  • It is proved to be 1000 times more effective than Piracetam.
  • Noopept doesn’t cause any serious toxicity or side effect.

10. Sulbutiamine

Sulbutiamine is derived from Vitamin B (Thiamine) in the lab. It is mainly involved in the production of energy, however, it also affects the production of the neurotransmitter dopamine.


Therefore, it is known to treat mental fatigue, enhance focus, and supercharge your motivation and mood.

Unlike Vitamin-B Sulbutiamine can cross the blood-brain barrier and modulate the dopaminergic, glutamatergic, and cholinergic receptors that influence our mood, concentration, and motivation [15].

Majorly the dopamine D1 receptor density is stimulated which increases motivation.

  • They play a vital role in enhancing the individual’s natural energy.
  •  It is an anti-fatigue nootropic supplement.
  • It increases the thiamine level and thus supercharges your motivation and mood.

11. Cordyceps

Do you like mushrooms? Did you know Cordyceps, is a type of mushroom having great nootropic and cognitive benefits?


Yes, another supplement that is becoming quite popular amongst the nootropic community is Cordyceps. It has long been used as a traditional medicine with a safe record of effective and potential benefits.

It consists of cordycepin, a substance that has the ability to reduce depression, anxiety and improve your memory and sleep. There is also evidence of the involvement of Cordyceps in supplementing the enzyme involved in the dopaminergic system.

In short, Cordyceps ensure more physical and mental energy, sharper cognition, elevated motivation and mood, and improved immunity with sleep.  

  • It is a kind of mushroom known for its general healing properties.
  • They are safe and effective to use.
  • It reverses depressive behavior and improves sleep.

12. Lion’s Mane

Lion’s Mane is also a type of mushroom known to have great health benefits. It is known to have the ability to improve various biological functions and cognitive abilities.

Lion's Mane

It has various nootropic benefits involving neurodegeneration, improved memory, and mood, and decreased anxiety.

Research has also shown that Lion’s Mane induces nerve growth factors, and modulates dopamine levels [16]. It lets you focus well, thus ensuring an extended period of motivation. It is beneficial for cognitive functions and is involved in boosting motivation.  

  • Used by people all over the world to reduce anxiety, inflammation and enhance mood and productivity.
  • In menopausal women, Lion’s Mane fights depression.
  • It induces the production of NGF involved in cognitive impairment.


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  2. Treadway M, Buckholtz J, Cowan R, et al. Dopaminergic mechanisms of individual differences in human effort-based decision-making. J Neurosci. 2012;32(18):6170-6176. doi:10.1523/JNEUROSCI.6459-11.2012
  3. Salamone JD, Correa M. The Mysterious Motivational Functions of Mesolimbic Dopamine. Neuron. Published online November 2012:470-485. doi:10.1016/j.neuron.2012.10.021
  4. Berridge KC, Robinson TE. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev. 1998 Dec;28(3):309–69. Review. PubMed PMID: 9858756.
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  6. Zheng X-Q, Ye C-X, Kato M, Crozier A, Ashihara H. Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha). Phytochemistry. Published online May 2002:129-134. doi:10.1016/s0031-9422(02)00086-9
  7. Murbach TS, Glávits R, Endres JR, et al. A Toxicological Evaluation of Methylliberine (Dynamine®). Journal of Toxicology. Published online October 27, 2019:1-25. doi:10.1155/2019/4981420
  8. Clarke R, Macrae R. Coffee: Physiology. Springer Science & Business Media; 1988.
  9. Eteng, M.U., Eyong, E.U., Akpanyung, E.O. et al. Recent advances in caffeine and theobromine toxicities: a review. Plant Foods Hum Nutr 51, 231–243 (1997).
  10.  Gerrard P, Malcolm R. Mechanisms of modafinil: A review of current research. Neuropsychiatr Dis Treat. 2007;3(3):349-364.
  11.  Holguin, S., Martinez, J., Chow, C., & Wurtman, R. (2008). Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. The FASEB Journal, 22(11), 3938-3946.
  12.  Testa B, Mayer JM. Hydrolysis in Drug and Prodrug Metabolism. Published online June 17, 2003. doi:10.1002/9783906390444
  13.  Shimidzu, T., Itoh, Y., Oka, M., Ishima, T., Ukai, Y., Yoshikuni, Y., & Kimura, K. (1997). Effect of a novel cognition enhancer NS-105 on learned helplessness in rats: possible involvement of GABA(B) receptor up-regulation after repeated treatment. European Journal of Pharmacology, 338(3):225-32.
  14.  Ostrovskaya RU, Gudasheva TA, Zaplina AP, et al. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med. Published online September 2008:334-337. doi:10.1007/s10517-008-0297-x
  15.  Trovero F, Gobbi M, Weil-Fuggaza J, Besson M-J, Brochet D, Pirot S. Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain. Neuroscience Letters. Published online September 2000:49-53. doi:10.1016/s0304-3940(00)01420-8
  16.  Li I-C, Lee L-Y, Tzeng T-T, et al. Neurohealth Properties ofHericium erinaceusMycelia Enriched with Erinacines. Behavioural Neurology. Published online 2018:1-10. doi:10.1155/2018/5802634
Erica Bail

Having specialized as a Neurologist for 8+ years treating patients with diseases like Parkinson's disease, Sclerosis, Dementia and Brain Injury. Dr Erica has the passion and experience to detect, diagnose and manage any type of brain disorder.

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