Hydrafinil Review: Effects, Dosage & Where to Buy


Nootropics are amazing supplements that can help you get through hours of work without becoming exhausted. But it can be difficult to choose which nootropic works the best for you. That’s where this article might be able to help you out. 

You’ve probably heard of Modafinil before. This drug is one of the most powerful nootropics on the market, but unfortunately, there are a number of adverse side effects associated with this drug. 

But what if there was a drug that was a safer alternative and would give you similar benefits to Modafinil?

If you’re looking for a drug like this then let us introduce you to Hydrafinil. This is an alternative to Modafinil that many people are not aware of. Although Hyfrafinil is not as powerful as Modafinil, this drug is still a great nootropic that gives powerful and consistent results. 

What is Hydrafinil?

To understand what Hydrafinil is, let’s look at what a nootropic is.

The term nootropic literally means that nootropic substances are those substances that can change the mind. This word was created by combining the Greek words ‘nóos’ and ‘trope’, which means ‘mind’ and ‘turning’. 

So how are nootropics able to ‘change the mind’? 

There are various ways in which nootropics can affect your brain. Some nootropic compounds also have neuroprotective properties, which help to maintain the cells of the brain. There are also antioxidants that prevent certain types of cell damage. This keeps your brain healthy and fit. 

The compounds in nootropics can change the brain’s chemistry by increasing the production of certain neurotransmitters or reducing it. These neurotransmitters are the compounds that our nerves use to interact with each other. Therefore by altering the levels of neurotransmitters in our brains, nootropics can give us some astounding results.

So what is Hydrafinil?

The easiest way to describe Hydrafinil is that it is a Modafinil alternative designed to promote wakefulness. Modafinil is a drug that has been shown to be an extremely effective nootropic[1]. Hydrafinil is able to produce similar effects without harmful side effects. In order to figure out why this drug is so effective, we’ll need to look a bit deeper.  

Hydrafinil is composed of a chemical known as Fluorenol or 9-hydroxyfluorene. This drug was created specifically to serve as a eugeroic alternative to Modafinil. Although Modafinil is an extremely useful and powerful nootropic, it had a ton of severe side effects. The harmful side effects that were caused by Modafinil meant that people could not use this drug on a daily basis. 

That is where Hydrafinil comes in. This drug was developed by a company named Cephalon that wanted to create a wakefulness agent that did not have the same harmful effects that Modafinil has. 

The result was a chemical compound known as fluorenol. This drug boosts alertness in the brain and can also ward off fatigue. Like Modafinil, Hydrafinil was created to boost productivity and increase focus. However, this drug primarily works by getting rid of brain fatigue. 

In one study, this drug showed that it was around 39% more effective than Modafinil in promoting wakefulness in mouse models[2]. There have also been other studies that show the powerful effects that this drug can have on people. 

But does this drug actually work?  

The online reviews and testimonials of this drug clearly show that there are many people who find this drug extremely useful. Additionally, all of the tests done on this drug showed positive results. More research needs to be done on this drug to understand the mechanism of action. However, for now, it is clear that the drug is safer than Modafinil and effective. 

Now let’s move on to the details of how this drug works. 

What Does Hydrafinil Do?

This drug gives similar effects to Modafinil. Some people also say that it is more potent than Modafinil at warding off fatigue. Hydrafinil promotes wakefulness, mental clarity, and alertness. 

It was primarily created to get rid of brain fatigue and allow a person to work long hours without being tired. Modafinil is the typical go-to drug for these scenarios but some research shows that Hydrafinil could be a better alternative. A study discovered that Hydrafinil was 39% more effective than Modafinil in animal studies. 

So how exactly is it able to do this?

The main reason this drug is so powerful is because of the way that it works. Like Modafinil, Hydrafinil is also a Central Nervous System stimulant which means that it stimulates your brain. It does this by regulating certain neurotransmitters like dopamine and serotonin.   

The way that it works is it increases the dopamine in the hypothalamus of the brain. Hydrafinil is a reuptake inhibitor of dopamine. It prevents the reuptake of dopamine which increases the amount of dopamine present in the brain. More dopamine increases the activity level of your brain which gives you more energy to work. Hydrafinil has also been shown to boost serotonin levels which is why it can improve your mood and make you feel better.

Hydrafinil Pharmacology

Although Hydrafinil is not very similar in structure to Modafinil, this drug has a lot of similar properties. The composition of this drug allows it to be a powerful nootropic that gives consistent results. 

The chemical compound is known as fluorenol[3]. This compound is formed when Hydroxyfluorene gets converted into alcohol and becomes fluorenol. Hydrafinil was created by a company in order to serve as an alternative for Modafinil therefore it has similar effects. 

Effects & Benefits

So we know that this product works but is it the right nootropic for you?

To figure this out let’s go over all of the benefits that Hydrafinil offers.

Enhances cognitive alertness.

If you’ve ever become frustrated because you find it difficult to stay focused then this drug might be helpful for you. By boosting the levels of dopamine in the brain, Hydrafinil is able to boost the alertness of the mind. It can be easy to get distracted when you’re trying to complete a long and complex task. Hydrafinil can solve this issue by allowing you to work on a task without getting distracted. 

Do keep in mind that Hydrafinil cannot provide the same level of intense focus that a medication like Adderall can give. However, this drug is perfect for people that need to be alert for long periods of time. 

Promotes Wakefulness.

All of us have experienced the feeling of sleepiness and fatigue after working on a boring task. When your brain gets fatigued, it can be difficult to work well and you might end up making silly mistakes. Hydrafinil gets rid of all that fatigue which helps you work longer. This is also great for individuals who need to pull all-nighters. 

Clears brain fog. 

Sometimes that morning cup of coffee just isn’t enough to wake you up. Hydrafinil provides something a bit stronger to get you started with your day. By boosting the serotonin and dopamine levels in your brain, Hydrafinil is able to give you mental clarity. This allows you to be more productive and start your day off fresh. 

Safer than Modafinil.

Finally one of the main benefits of Hydrafinil is the fact that it is a safer alternative to Modafinil. Modafinil is currently classified as a Schedule IV drug which means that the drug is slightly addictive. This makes it safer than some drugs on the market like Adderall, but it is still a risky substance to use. Modafinil is also quite potent and can cause some adverse side effects. This is why it cannot be used regularly. 

On the other hand, Hydrafinil is able to give the same results as Modafinil without the same risks. Most people that use Hydrafinil do not experience any side effects. The side effects that are caused by this drug are also milder than the ones that are caused by Modafinil. Although more research needs to be done into this drug, the majority of the reviews say that this drug is a safer alternative. 

How Does Hydrafinil Work?

This drug was created as an alternative to Modafinil therefore it works similarly to it. The chemical compound of Hydrafinil is quite different in structure to Modafinil. But the effects that are produced by this drug are quite similar to those produced by Modafinil. 

Research has shown that Modafinil and other analogs work by binding to the Dopamine Transporter(known as DAT)[4]. This dopamine transporter is responsible for transporting the dopamine molecules so that it can get taken up by the cells. By inhibiting the function of the DAT, Modafinil is able to keep the levels of dopamine in the brain high. 

However, Hydrafinil does not work in this manner. It is a weak DAT inhibitor and has a much weaker binding ability than Modafinil. There are other mechanisms that Hydrafinil uses to keep dopamine levels high in the brain but more research needs to be done to properly understand these mechanisms. Because of this, the effects of Hydrafinil last shorter than Modafinil. This unique mechanism of action might also explain why Hydrafinil is so effective. 

Now that we’ve gone over how this drug works, let’s go into how you can use it. 

Dosage & How to Take

It is difficult to tell exactly what dosage is the right one for Hydrafinil because there are no official clinical trials. We also do not know exactly how this drug works in humans and therefore it is best to excise utmost precaution. In order to get a gist of the most effective dosage of this drug, we looked at online reviews. 

Most of the reviewers claimed that they did not experience any harmful effects while using around 20 to 250 mg of Hydrafinil. Generally, people experienced moderate effects at 25 mg and the euphoric effects began to set in at around 100 mg. It is advisable that you begin at 25 to 50 mg and then increase the dose according to your preference. 

This nootropic is meant for a short burst of productivity therefore it is recommended that you take Hydrafinil around 30 to 45 minutes before you begin work. Generally, Hydrafinil will give you around 5 to 6 hours of productivity. If you need to pull an all-nighter or work for 12 hours in a row then a drug like Modafinil might be more effective for you. However, Hydrafinil is a great nootropic for a short boost of energy.

Side Effects

The side effects of Hydrafinil are quite mild as compared to other synthetic nootropics like Modafinil. This is one of the main reasons why people use Hydrafinil. However, there are a few significant side effects that can be seen like eye irritation, skin irritation, respiratory and digestive tract irritation[5]. Most of the reviews we looked at said that the side effects were quite mild and did not persist after they continued using this drug. Some individuals experienced more severe side effects like nausea, headaches and other similar issues. 

These symptoms are quite rare so the majority of the people who take this nootropic will not experience it. However, when it comes to nootropics it is best to take as many precautions as necessary. We recommend starting with a small dose to see how your body reacts to the drug. If you tend to have an adverse reaction to new medication then it’s a good idea to contact a medicinal professional if you notice any of these symptoms.  

Experiences Shared on Reddit

Reddit is the best place to look up product reviews. This platform has a ton of reviews from people that have plenty of experience with nootropics. It can be a great resource especially for people who are unfamiliar with nootropics.

So what do people think of Hydrafinil? 

In general, the overall reviews range from positive to neutral. Some individuals find that Hydrafinil is by far the best nootropic drug they have used. On the other hand, there are also people who did not feel the effects of Hydrafinil and went back to using more powerful drugs. 

Additionally, many of the reviewers expressed their concern by the lack of research available for Hydrafinil. They preferred using other Modafinil analogs like Armodafinil instead. 

Basically, the majority of the reviews are positive while some of them believe that other nootropics are more effective. A lot of people mentioned that the lack of research had made it difficult for them to assess the safety of the drug. The reviews also show that the side effects of this product are quite minimal but some people did experience skin irritation.

Hydrafinil Legality

Unfortunately because of the fact that there are no official clinical trials of Hydrafinil, this drug is not certified as an FDA-approved drug. Additionally, because it is a Modafinil analog, it is best to buy these drugs from a verified vendor. 

Most online platforms that sell this drug will give you a disclaimer that this drug is primarily meant for research purposes. This is due to the fact that there is very little research on Hydrafinil. It is also illegal to resell this drug unless it is for research purposes. 

Where to Buy Hydrafinil Online

Adrafinil is not an FDA-approved drug which can make it difficult to acquire. However, there are numerous stores online that sell the drug. We recommend that you only purchase this drug from trusted sources that are verified. 

For example, Science Bio is a great place to purchase Hydrafinil. Science Bio is a website that is known for selling quality research chemicals. Ensure that before you purchase or consume any products from online sites that you look up reviews about the site. This will help you to get a quality product. 

Frequently Asked Questions (FAQ)

How Long Does It Last?

Generally, Hydrafinil does not last as long as other nootropics like Modafinil. You can expect around 5 to 6 hours from a small dose. Increasing the dosage might give you more hours of productivity. Do keep in mind that every person’s body is different. However, this drug is typically only meant for a short burst of productivity.

What is the Difference Between Hydrafinil and Adrafinil?

This is another drug that gives similar benefits to Modafinil. Like Hydrafinil, Adrafinil was also created to give similar effects to Modafinil and Adrafinil does not have side effects that are as severe as Modafinil. Much like Hydrafinil, This drug does not have a ton of research available to back it up, but the research shows that Adrafinil is an effective alternative. 

So how exactly does this drug works? And is it a better Modafinil alternative than Hydrafinil?

Adrafinil acts as a prodrug. This means that when it is consumed, it gets metabolized into Modafinil inside the body. This method allows Adrafinil to give similar effects to Modafinil, but it takes a bit longer to start working. Not much research has been done on Adrafinil, but it has been shown to boost cognitive functioning and helps to reduce fatigue in the brain. Like Modafinil, this drug should also be used with caution. 

Hydrafinil, on the other hand, is better for short bursts of productivity. To summarize, Adrafinil makes the perfect Modafinil alternative for people who want drugs that take a longer time to work but give the same effects as Modafinil. Hydrafinil excels as a wakefulness drug that works for a shorter period of time.


We’ve gone over a ton of information in this article so let’s go over everything quickly. In short, Hydrafinil is a great Modafinil alternative that primarily works as a wakefulness agent. It works for a shorter period of time as compared to Modafinil.  It is also safer than Modafinil and has fewer side effects. 

The downsides of this drug are that there is a severe lack of research for this drug. This drug is not FDA-approved and it is difficult to acquire. 

If you’re looking for a wakefulness agent that is an alternative to Modafinil then this is a great option for you. However, if you want a long-lasting drug Modafinil or an alternative live Adrafinil or Armodafinil is better. Additionally, other natural nootropics like Qualia Mind might be better for daily use.

Erica Bail

Having specialized as a Neurologist for 8+ years treating patients with diseases like Parkinson's disease, Sclerosis, Dementia and Brain Injury. Dr Erica has the passion and experience to detect, diagnose and manage any type of brain disorder.

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