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Piracetam: Reviews, Dosage, Effects & Where to Buy

piracetam-review

Our lives have become incredibly hectic and sometimes a cup of coffee just isn’t enough. It’s impossible to get rid of your brain fog and get mental clarity from a regular old cup of coffee. In that case, we have something that is sure to make your life a whole lot easier. 

Piracetam is a nootropic that has been used for ages as a cognitive and dietary supplement. This drug was created by the scientist who coined the term ‘nootropic’. It is a well-known drug that can boost brain health[1]. But is it the right nootropic for you?

In general, nootropics are substances that are able to change the functions of your brain. The way that nootropics work is they alter the level of certain neurotransmitters. This can give you powerful benefits that will last for hours. 

However, because of the sheer amount of nootropics on the market, it can be hard to know which benefits are fact and which are fiction. 


That’s where this article comes in.  We’re going to give you a complete rundown of Piracetam. By the end of this article, you’ll know how this drug works, what the uses of this drug are 

Overview -What is Piracetam?

Piracetam has the unique distinction of being one of the first nootropics to be created. In 1964, Dr. Corneliu Giurgea created this drug as a derivative of the neurotransmitter GABA. Giurgea is well-known for creating the term nootropic in 1972 and he was also responsible for creating a set of requirements for nootropics. 

Ever since it was created, Piracetam has been used for its cognitive boosting effects. When it was first produced, this drug was used as a prescription medication for myoclonus or muscle spasms and for dementia. Over time this drug showed that it had many other cognitive and physical benefits. This is probably why this drug is still used all over the world.

This nootropic is used as a dietary supplement in Europe and is an OTC nootropic in America. Although there is still a lot of research that needs to be done, it is clear that this drug is effective.


So now that you know the basics of this drug, let’s take a look at how Piracetam works. 

How does it work?

Piracetam was created as a derivative of GABA, an important neurotransmitter. However, this drug does not interact with the GABA neuroreceptors that are found in the brain. The way that Piracetam works are not exactly known, however, we do know that it increases the effect of acetylcholine in the brain. By increasing the levels of acetylcholine, the drug is able to boost focus and concentration in the mind. 

It also has an effect on the ion channels that are found on the surface of the neurons in our brain. The neurons of the brain use ions to communicate with each other. All of the nerves in our body rely on these ions to perform their day-to-day function. Thus Piracetam is able to utilize this to its advantage. 

This is likely the reason why Piracetam is able to boost cognitive functioning. It has also been used as a treatment of myoclonus[2]. The muscle spasms that are seen in myoclonus can be alleviated by Piracetam because of the fact that it can affect the ion channels in the body. 

Piracetam is a quite unique nootropic because it is able to alter the membrane of cells[3]. It helps to modify certain properties of the membrane but this mechanism of action is not entirely understood. This means that Piracetam has also been used to treat conditions like sickle cell anemia[4]. 

Although we don’t know exactly how Piracetam works in the body, there is a ton of research being done on this drug to figure out how exactly it works. In the future, we will hopefully be able to utilize the full potential of this nootropic. 

So it’s clear that Piracetam has many mechanisms of action but how effective is it? Let’s break down how this drug can help you. 

Uses & Effectiveness?

Unlike most prescription nootropics, Piracetam has a unique mode of action. This means that this drug can be used to treat a variety of symptoms and illnesses. However, it is important to keep in mind that it is highly effective in some situations but not as effective in others. In order to understand whether or not this drug is the right one for you, you’ll need to do some thorough research into the benefits of Piracetam. 

We have given you some of the effects of Piracetam as well as some of the downsides: 

Possibly Effective for

Piracetam is a nootropic and thus it is able to boost cognition and increase focus. There have been multiple studies that have shown that this drug has a huge effect on the central nervous system[5]. By altering the way that the neurons in the brain communicate, Piracetam is able to effectively increase focus in the brain. This has also been shown to alleviate symptoms of nerve damage done in patients with Alzheimer’s[6]. It has also been used to treat other nervous system disorders[7]. 

This drug also has a significant effect on the membrane of the cells. It is able to alter it and help alleviate certain symptoms from diseases that affect these membranes. For example, sickle cell anemia is one disease that Piracetam has been quite effective for. 

Apart from this, there have also been several promising tests done on animal models. Piracetam has been shown to be extremely effective in bettering the symptoms of certain nervous system disorders[8]. There are also studies that show that it is effective in reducing and alleviating some of the adverse symptoms associated with alcohol addiction[9].

However, despite the fact that there are a ton of benefits to this drug, there is one downside you need to keep in mind. 

Insufficient Evidence for

This drug is a great nootropic drug for a variety of uses. However, more research needs to be done into the benefits of this drug. It is clear that they have significant cognitive benefits for some medical conditions like dementia, certain other symptoms of aging and even coagulation but there is not much evidence that it offers the same cognitive benefits for healthy individuals. 

This is mainly due to the fact that the majority of the studies done on Piracetam have been based on their medicinal ability. Even though there is no definitive proof that this drug works well as a nootropic in healthy individuals, it is clear that it is still a good dietary supplement. 

In one study of healthy individuals, it was shown that there was no sufficient evidence that this drug had a massive benefit on cognition[10]. However, there have also been other studies that show that Piracetam increases the memory retention ability in some individuals over long periods of time[11]. There are only a few studies on this topic because of the fact that the bulk of the research has been done about the therapeutic abilities of Piracetam. 

Unfortunately, currently we do not have enough evidence to say that Piracetam is an extremely effective nootropic for healthy individuals. If you are only looking for a nootropic and not a dietary supplement, then we recommend looking at other more effective nootropic drugs like Modafinil

5 Benefits of Piracetam (Plus Side Effects)

Piracetam offers plenty of benefits and we’ve narrowed down the 5 most important benefits of this drug to help you decide whether it is right for you. Do keep in mind that everyones body is different and this drug might not give you the exact same results as it gives someone else. To solve this issue, we recommend trying Piracetam out for a while to see if it works well for you.

Without further ado, let’s get started: 

1. May boost brain function

Some studies show that Piracetam boosts cognition and verbal memory in individuals. The drug is able to boost acetylcholine production in the brain which increases focus. A majority of these studies have been conducted on individuals with a nervous system disorder or a similar disease, but there are some studies that show a similar benefit in healthy individuals.

2. May reduce dyslexia symptoms

Dyslexia is a learning disorder that affects the learning ability of a person. It can make it difficult to read certain words and memorize things. Piracetam can help to lessen these symptoms in some individuals. It does this by altering the acetylcholine in our brains. 

3. May protect against myoclonic seizures

Piracetam is a popular medication for myoclonus. It is able to stop or lessen the impact of these seizures and is used for epileptic seizures. This is because Piracetam can alter the way that the ion channels work. These channels are responsible for sending signals between nerves. Therefore Piracetam is effective against these seizures. 

4. May reduce dementia and symptoms of Alzheimer’s disease

Alzheimer’s disease is an incredibly damaging illness that can severely impact a person’s life. Piracetam has been shown to reduce some of the effects of dementia and neural damage in the brain of individuals with Alzheimer’s. One study found that Piracetam was able to reduce the amount of neuronal loss in a person’s brain and thus help their cognitive abilities[12]. Although more research needs to be done, it is clear that this drug shows great promise. 

5. May reduce inflammation and provide pain relief

This drug is able to increase blood circulation to the brain and also reduce inflammation. This helps to give pain relief and also increases the amount of oxygen that is supplied to the brain. This can give your brain more energy and help you to work faster. 

Dosage and recommendations

A dose of around 1000 to 1300 mg will last for a few hours. It is recommended that you take around 3 doses of this medication a day. However, everyone’s body works differently and you will need to figure out what is best for you. 

Side Effects

The side effects of Piracetam are quite mild as compared to other synthetic nootropics. However, there are a few significant side effects that can be seen like:

  • Nausea
  • Headaches
  • Anxiety
  • Irritability 
  • Tremors

These symptoms are quite rare so the majority of the people who take this nootropic will not experience it. However, it is also best to take precautions when you are taking medications. 

Special Precautions and Warnings

Nootropics are incredibly useful substances that can help you to stay focused for hours on end and Piracetam is the same. This drug has a ton of useful benefits and has been tested thoroughly. 

However, there are a few things that you should know before taking the drug. Due to the nature of Piracetam, this drug is very powerful and it should be taken with caution. 

Experiences Shared on Reddit

If you want to look up good product reviews, then Reddit is the perfect place to do that. So, what do the people on this platform have to say about Piracetam?

In general, the overall reviews range from positive to neutral. Some individuals find that Piracetam is by far the best nootropic drug they have used. However, many of them have mentioned that the drug took some time to start working. Others feel like the drug isn’t as powerful as some other alternatives.

Basically, the majority of the reviews are positive while some of them believe that other nootropics are more effective. The reviews also show that the side effects of this product are quite minimal. 

Piracetam Stacks

There are a wide variety of racetams and nootropics that are available on the market. Some of them are better than Piracetam in certain aspects. Stacking nootropics can help you to enhance the effectiveness of a particular nootropic. Piracetam stacks well with most nootropics however we recommend that you contact your medical professional before stacking nootropics. 

Choline

Choline is a nutrient that is found in a variety of foods. This substance is used as a dietary supplement and it is a precursor of acetylcholine. This means that increasing the amount of choline in your system also boosts acetylcholine medication which boosts focus. Studies have also shown that when you combine choline and Piracetam, it can give you a ton of beneficial nootropic effects[13]. Stacking Choline with Piracetam is a great option for those people looking for something stronger than Piracetam. 

Other Racetams & Nootropics

Piracetam might have been the first racetam but there were a variety of other racetams produced later that are effective nootropics. A racetam is a group of compounds that contain a chemical known as pyrrolidone. There are a variety of racetams that work well as nootropics however all of them don’t fall into this box. Some racetams are anticonvulsants and are used to treat seizures. 

These drugs are amongst the first nootropic drugs that were ever produced. But do they actually work?

Even though they belong to the same group of chemicals, all racetams work differently. Over here we’ll look at some of the most common drugs in this group. 

The first one we’ll look at is Aniracetam. This drug increases the effects of an important neurotransmitter known as glutamate. This helps to boost focus and concentration in the brain which can help you to work longer. Nefiracetam boosts the release of GABA in the brain which relaxes the mind. If you tend to get frustrated and stressed, this racetam is for you. Oxiracetam is a good nootropic for students and professionals as it clears brain fog and boosts cognition. 


There are also a large variety of other racetams available on the market. 

Where to Buy Piracetam Powder & Capsules?

In most places, Piracetam is found in many stores and is sold as an OTC drug. It does not require a prescription to use. There are also a few online retailers that sell this product but we recommend that you get this drug from a trusted source in order to ensure your safety. 

Frequently Asked Questions (FAQ)

Is It Safe?

Since the invention of Piracetam in 1964 till today there have been countless tests done on this product. All of them have shown that Piracetam is a safe drug to take and it has relatively minimal side effects as compared to other nootropic drugs. 


However, do keep in mind that it is always best to be cautious when you are taking a nootropic. 

Is It Legal?

Yes, Piracetam is a legal drug that you can purchase easily. 

How to Take Piracetam?

Typically Piracetam is ingested orally via a small capsule. However, there are also powder packets that are available on the market. 

How Long Does It Last?

Generally, a single dose of Piracetam does not last extremely long. The recommended dosage for this drug is around three capsules a day. However, this depends on the individual who takes the doses. Start off with the regular dose and then alter it according to your preferences. 


Do keep in mind that it will take a few weeks for the full effects of Piracetam to kick in. This drug is meant to be used as a long-term drug. 

Conclusion

To sum it up, Piracetam is a nootropic drug that is extremely useful for treating a variety of conditions. This drug is great for individuals who need to boost their cognitive abilities and focus their minds. Piracetam is primarily meant to be used by people who have certain ailments like memory loss but it can also be used by healthy individuals. 

It is also a treatment for myoclonus. Piracetam can also be used as a dietary supplement to strengthen your cells. It is able to treat some symptoms of certain conditions like sickle cell anemia. If you are considering Piracetam as a medication then we recommend that you speak to a medical professional before making a final decision. Piracetam is also one of the safer synthetic nootropics on the market and it has shown to be effective for a wide variety of uses. 

Remember that if you need a powerful nootropic that will help you work for hours on end then a nootropic like Modafinil might be better for you. 

We hope that this article has given you all the information you need to make the right choice.

References:

  1. Winblad B. (2005). Piracetam: a review of pharmacological properties and clinical uses. CNS drug reviews, 11(2), 169–182. https://doi.org/10.1111/j.1527-3458.2005.tb00268.x
  2. Ikeda, A., Shibasaki, H., Tashiro, K., Mizuno, Y., & Kimura, J. (1996). Clinical trial of piracetam in patients with myoclonus: nationwide multi institutional study in Japan. The Myoclonus/Piracetam Study Group. Movement disorders : official journal of the Movement Disorder Society, 11(6), 691–700. https://doi.org/10.1002/mds.870110615
  3. Müller, W. E., Eckert, G. P., & Eckert, A. (1999). Piracetam: novelty in a unique mode of action. Pharmacopsychiatry, 32 Suppl 1, 2–9. https://doi.org/10.1055/s-2007-979230
  4. El-Hazmi, M. A., Al-Fawaz, I., Warsy, A., Opawoye, A., Taleb, H., Howsawi, Z., Mohamed, A., Wadood Aly, A., Refai, S., Sugathan, P., Rab, A., Ahmed, H., Abulaban, M., Abdulkader, A., & Farid, M. (1998). Piracetam for the treatment of sickle cell disease in children- a double blind test. Saudi medical journal, 19(1), 22–27.
  5. Malykh, A. G., & Sadaie, M. R. (2010). Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders. Drugs, 70(3), 287–312. https://doi.org/10.2165/11319230-000000000-00000
  6. Croisile, B., Trillet, M., Fondarai, J., Laurent, B., Mauguière, F., & Billardon, M. (1993). Long-term and high-dose piracetam treatment of Alzheimer’s disease. Neurology, 43(2), 301–305. https://doi.org/10.1212/wnl.43.2.301
  7. Chouinard, G., Annable, L., Ross-Chouinard, A., Olivier, M., & Fontaine, F. (1983). Piracetam in elderly psychiatric patients with mild diffuse cerebral impairment. Psychopharmacology, 81(2), 100–106. https://doi.org/10.1007/BF00429000
  8. Cohen, S. A., & Müller, W. E. (1993). Effects of piracetam on N-methyl-D-aspartate receptor properties in the aged mouse brain. Pharmacology, 47(4), 217–222. https://doi.org/10.1159/000139100
  9. Brandão, F., Cadete-Leite, A., Andrade, J. P., Madeira, M. D., & Paula-Barbosa, M. M. (1996). Piracetam promotes mossy fiber synaptic reorganization in rats withdrawn from alcohol. Alcohol (Fayetteville, N.Y.), 13(3), 239–249. https://doi.org/10.1016/0741-8329(95)02050-0
  10. Sannita, W. G., Balestra, V., Rosadini, G., Salama, M., & Timitilli, C. (1985). Quantitative EEG and neuropsychological effects of piracetam and of the association piracetam-lecithin in healthy volunteers. Neuropsychobiology, 14(4), 203–209. https://doi.org/10.1159/000118228
  11. Dimond, S. J., & Brouwers, E. M. (1976). Increase in the power of human memory in normal man through the use of drugs. Psychopharmacology, 49(3), 307–309. https://doi.org/10.1007/BF00426834
  12. Brandão, F., Paula-Barbosa, M. M., & Cadete-Leite, A. (1995). Piracetam impedes hippocampal neuronal loss during withdrawal after chronic alcohol intake. Alcohol (Fayetteville, N.Y.), 12(3), 279–288. https://doi.org/10.1016/0741-8329(94)00107-oB
  13. Bartus, R. T., Dean, R. L., 3rd, Sherman, K. A., Friedman, E., & Beer, B. (1981). Profound effects of combining choline and piracetam on memory enhancement and cholinergic function in aged rats. Neurobiology of aging, 2(2), 105–111. https://doi.org/10.1016/0197-4580(81)90007-5
Erica Bail

Having specialized as a Neurologist for 8+ years treating patients with diseases like Parkinson's disease, Sclerosis, Dementia and Brain Injury. Dr Erica has the passion and experience to detect, diagnose and manage any type of brain disorder.

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